Assay Detail
Functional
CHEMBL747777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.67 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274329 | — | — | 1 | 7.13 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.08 |
| CHEMBL275104 | — | — | 1 | 6.67 |
| CHEMBL8610 | — | — | 1 | 6.63 |
| CHEMBL8510 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274329 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL275104 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL8610 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL8510 | — | IC50 | = | 1380.0 | nM | 5.86 |