Assay Detail
Functional
CHEMBL747799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for inhibition of proliferation in BDF1 mouse spleen cells stimulated with concanavalin A (ConA).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Spleen |
| Cell Type | spleen |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.11 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216520 | — | — | 1 | 7.70 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.40 |
| CHEMBL2370707 | — | — | 1 | 6.98 |
| CHEMBL2370706 | — | — | 1 | 6.85 |
| CHEMBL2370711 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216520 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2370707 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2370706 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL2370711 | — | IC50 | = | 248.0 | nM | 6.61 |