Assay Detail
Binding
CHEMBL747857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of (-)-[3H]nicotine binding to rat brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.28 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149667 | — | — | 1 | 8.30 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.15 |
| CHEMBL25619 | — | — | 1 | 8.10 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 7.10 |
| CHEMBL148848 | — | — | 1 | 6.05 |
| CHEMBL423579 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3 | NICOTINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL25619 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL6200 | NORNICOTINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL148848 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL423579 | — | IC50 | = | 1000.0 | nM | 6.00 |