Compound Detail
CHEMBL148848
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Basic Information
| ChEMBL ID | CHEMBL148848 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCYJRWZUNGLGJL-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
188.3
MW (Da)
2.13
ALogP
2
HBA
1
HBD
24.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetylcholine receptor CHEMBL2096975 | IC50 | 6.52 | 6.52 | 300.0 | 2 |
| Neuronal acetylcholine receptor CHEMBL2094110 | IC50 | 6.16 | 6.105 | 700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetylcholine receptor | IC50 | = | 300.0 | nM | 6.52 | inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranes | 3346870 |
| Acetylcholine receptor | IC50 | = | 300.0 | nM | 6.52 | Inhibition of [3H]MCC binding to torpedo electroplax membranes | 3346870 |
| Neuronal acetylcholine receptor | IC50 | = | 700.0 | nM | 6.16 | Inhibition of [3H]MCC binding to rat brain membranes | 3346870 |
| Neuronal acetylcholine receptor | IC50 | = | 900.0 | nM | 6.05 | Inhibition of (-)-[3H]nicotine binding to rat brain membranes | 3346870 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3346870 | 10.1021/jm00398a004 | Neuronal acetylcholine receptor | 4 |
| 3346870 | 10.1021/jm00398a004 | Acetylcholine receptor | 4 |
| 3346870 | 10.1021/jm00398a004 | Rattus norvegicus | 2 |
Data from ChEMBL 36 via Core Engine