Assay Detail
Binding
CHEMBL748732
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inhibition of (-)-[3H]nicotine binding to torpedo electroplax membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25619 | — | — | 1 | 9.00 |
| CHEMBL149667 | — | — | 1 | 9.00 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 8.40 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 7.00 |
| CHEMBL148848 | — | — | 1 | 6.52 |
| CHEMBL423579 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25619 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL149667 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3 | NICOTINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL6200 | NORNICOTINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL148848 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL423579 | — | IC50 | = | 800.0 | nM | 6.10 |