Assay Detail
Binding
CHEMBL748008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]TCP from tissue homogenate preparation of whole rat brain minus cerebellum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.54 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 6.98 |
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 6.97 |
| CHEMBL310262 | — | — | 1 | 5.64 |
| CHEMBL307469 | — | — | 1 | 5.43 |
| CHEMBL3990514 | LEVOXADROL | 2.0 | 1 | 4.91 |
| CHEMBL1794813 | — | — | 1 | 4.42 |
| CHEMBL1794815 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL305904 | ETOXADROL | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL310262 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL307469 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL3990514 | LEVOXADROL | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL1794813 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL1794815 | — | Ki | = | 40000.0 | nM | 4.40 |