Assay Detail
Binding
CHEMBL748019
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Binding affinity value obtained by measuring the displacement of radioligand [3H](-)-cytisine from whole rat brain Nicotinic acetylcholine receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.07 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127071 | POZANICLINE | 2.0 | 1 | 7.78 |
| CHEMBL84692 | — | — | 1 | 7.57 |
| CHEMBL126692 | — | — | 1 | 7.41 |
| CHEMBL129609 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127071 | POZANICLINE | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL84692 | — | Ki | = | 27.2 | nM | 7.57 |
| CHEMBL126692 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL129609 | — | Ki | = | 3000.0 | nM | 5.52 |