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Compound Detail

CHEMBL129609

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Cc1ncccc1OC[C@H]1CCCN1C

Basic Information

ChEMBL ID CHEMBL129609
Phase Preclinical
Structure Type MOL
InChI Key RJVWDVTXZQWCCU-LLVKDONJSA-N
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
5
Publications
0
Known Names

Molecular Properties

206.3
MW (Da)
1.86
ALogP
3
HBA
0
HBD
25.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H18N2O
MW 206.29
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -0.49

Activity Summary

Ki 1 meas. best 5.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor
CHEMBL2094110
Ki 5.52 5.52 3000.0 1

Pharmacokinetic Data

Parameter Value Units Species
F 4.9 % Canis lupus familiaris
T1/2 8.5 hr Canis lupus familiaris
T1/2 0.61 hr Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9022806 10.1021/jm960233u IMR-32 2
9022806 10.1021/jm960233u Canis familiaris 2
9022806 10.1021/jm960233u Neuronal acetylcholine receptor 1
9022806 10.1021/jm960233u Neuronal acetylcholine receptor subunit alpha-7 1
9022806 10.1021/jm960233u ADMET 1

Data from ChEMBL 36 via Core Engine