Assay Detail
Binding
CHEMBL748168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against muscarinic receptor using radioligand [3H]quinuclidinyl benzilate (QNB) binding assay in membrane preparations of rat neocortex.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Neocortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
()-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.14 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156050 | — | — | 1 | 7.82 |
| CHEMBL351561 | — | — | 1 | 7.68 |
| CHEMBL160582 | — | — | 1 | 7.36 |
| CHEMBL348412 | — | — | 1 | 7.19 |
| CHEMBL405426 | — | — | 1 | 7.09 |
| CHEMBL156445 | — | — | 1 | 7.06 |
| CHEMBL346580 | — | — | 1 | 6.77 |
| CHEMBL345415 | — | — | 1 | 6.74 |
| CHEMBL160939 | — | — | 1 | 6.66 |
| CHEMBL345205 | — | — | 1 | 6.42 |
| CHEMBL434469 | — | — | 1 | 6.42 |
| CHEMBL160541 | — | — | 1 | 6.36 |
| CHEMBL348079 | — | — | 1 | 6.22 |
| CHEMBL346123 | — | — | 1 | 6.17 |
| CHEMBL86903 | — | — | 1 | 6.09 |
| CHEMBL160858 | — | — | 1 | 6.01 |
| CHEMBL158180 | — | — | 1 | 5.97 |
| CHEMBL160928 | — | — | 1 | 5.91 |
| CHEMBL157198 | — | — | 1 | 5.85 |
| CHEMBL160554 | — | — | 1 | 5.82 |
| CHEMBL84726 | — | — | 1 | 5.80 |
| CHEMBL157197 | — | — | 1 | 5.70 |
| CHEMBL87622 | — | — | 1 | 5.69 |
| CHEMBL156749 | — | — | 1 | 5.62 |
| CHEMBL156925 | — | — | 1 | 5.56 |
| CHEMBL345250 | — | — | 1 | 5.46 |
| CHEMBL434072 | — | — | 1 | 5.37 |
| CHEMBL160288 | — | — | 1 | 5.25 |
| CHEMBL159208 | — | — | 1 | 5.07 |
| CHEMBL160509 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156050 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL351561 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL160582 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL348412 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL405426 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL156445 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL346580 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL345415 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL160939 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL345205 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL434469 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL160541 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL348079 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL346123 | — | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL86903 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL160858 | — | IC50 | = | 968.0 | nM | 6.01 |
| CHEMBL158180 | — | IC50 | = | 1073.0 | nM | 5.97 |
| CHEMBL160928 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL157198 | — | IC50 | = | 1413.0 | nM | 5.85 |
| CHEMBL160554 | — | IC50 | = | 1514.0 | nM | 5.82 |
| CHEMBL84726 | — | IC50 | = | 1587.0 | nM | 5.80 |
| CHEMBL157197 | — | IC50 | = | 1992.0 | nM | 5.70 |
| CHEMBL87622 | — | IC50 | = | 2063.0 | nM | 5.69 |
| CHEMBL156749 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL156925 | — | IC50 | = | 2742.0 | nM | 5.56 |
| CHEMBL345250 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL434072 | — | IC50 | = | 4234.0 | nM | 5.37 |
| CHEMBL160288 | — | IC50 | = | 5593.0 | nM | 5.25 |
| CHEMBL159208 | — | IC50 | = | 8547.0 | nM | 5.07 |
| CHEMBL160509 | — | IC50 | = | 19308.0 | nM | 4.71 |
| CHEMBL14 | CARBACHOL | IC50 | = | 33000.0 | nM | 4.48 |