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Compound Detail

CHEMBL84726

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C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2

Basic Information

ChEMBL ID CHEMBL84726
Phase Preclinical
Structure Type MOL
InChI Key FYVBKGRFGASYCS-YYWHJSAJSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

280.4
MW (Da)
2.69
ALogP
3
HBA
0
HBD
24.8
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H20N2O
MW 280.37
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness 0.22

Activity Summary

IC50 6 meas. best 7.91

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.91 6.855 12.4 4
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 5.96 5.96 1090.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
IC50 5.1 5.1 7930.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00087-A Muscarinic acetylcholine receptor 3
9651157 10.1021/jm960683m Muscarinic acetylcholine receptor 3
9651157 10.1021/jm960683m Muscarinic acetylcholine receptor M2 1
9651157 10.1021/jm960683m Muscarinic acetylcholine receptor M1 1
9651157 10.1021/jm960683m Muscarinic acetylcholine receptors; M1 & M2 1

Data from ChEMBL 36 via Core Engine