Assay Detail
Binding
CHEMBL748601
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Binding affinity against muscarinic receptor using radioligand [3H]cis-methyldioxolane (CMD) binding assay in membrane preparations of rat neocortex.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Neocortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
()-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.55 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351561 | — | — | 1 | 10.70 |
| CHEMBL156050 | — | — | 1 | 10.52 |
| CHEMBL350223 | — | — | 1 | 10.00 |
| CHEMBL160582 | — | — | 1 | 9.82 |
| CHEMBL405426 | — | — | 1 | 9.35 |
| CHEMBL156445 | — | — | 1 | 9.28 |
| CHEMBL348412 | — | — | 1 | 9.24 |
| CHEMBL346580 | — | — | 1 | 9.10 |
| CHEMBL86903 | — | — | 1 | 9.00 |
| CHEMBL345415 | — | — | 1 | 8.97 |
| CHEMBL160928 | — | — | 1 | 8.86 |
| CHEMBL160939 | — | — | 1 | 8.79 |
| CHEMBL87622 | — | — | 1 | 8.40 |
| CHEMBL348079 | — | — | 1 | 8.39 |
| CHEMBL434469 | — | — | 1 | 8.35 |
| CHEMBL159208 | — | — | 1 | 8.34 |
| CHEMBL160858 | — | — | 1 | 8.30 |
| CHEMBL345205 | — | — | 1 | 8.30 |
| CHEMBL156749 | — | — | 1 | 8.27 |
| CHEMBL345250 | — | — | 1 | 8.19 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 8.17 |
| CHEMBL158180 | — | — | 1 | 8.01 |
| CHEMBL157198 | — | — | 1 | 7.92 |
| CHEMBL434072 | — | — | 1 | 7.92 |
| CHEMBL84726 | — | — | 1 | 7.91 |
| CHEMBL156925 | — | — | 1 | 7.88 |
| CHEMBL160554 | — | — | 1 | 7.82 |
| CHEMBL157197 | — | — | 1 | 7.77 |
| CHEMBL160509 | — | — | 1 | 7.68 |
| CHEMBL346123 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351561 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL156050 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL350223 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL160582 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL405426 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL156445 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL348412 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL346580 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL86903 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL345415 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL160928 | — | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL160939 | — | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL87622 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL348079 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL434469 | — | IC50 | = | 4.45 | nM | 8.35 |
| CHEMBL159208 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL160858 | — | IC50 | = | 4.96 | nM | 8.30 |
| CHEMBL345205 | — | IC50 | = | 5.02 | nM | 8.30 |
| CHEMBL156749 | — | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL345250 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL14 | CARBACHOL | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL158180 | — | IC50 | = | 9.75 | nM | 8.01 |
| CHEMBL157198 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL434072 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL84726 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL156925 | — | IC50 | = | 13.27 | nM | 7.88 |
| CHEMBL160554 | — | IC50 | = | 15.31 | nM | 7.82 |
| CHEMBL157197 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL160509 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL346123 | — | IC50 | = | 22.16 | nM | 7.65 |
| CHEMBL160541 | — | IC50 | = | 27.12 | nM | 7.57 |
| CHEMBL160288 | — | IC50 | = | 80.47 | nM | 7.09 |