Assay Detail
Binding
CHEMBL744238
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Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.37 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312823 | — | — | 1 | 6.67 |
| CHEMBL84726 | — | — | 1 | 5.96 |
| CHEMBL85264 | — | — | 1 | 5.95 |
| CHEMBL86903 | — | — | 1 | 5.80 |
| CHEMBL85936 | — | — | 1 | 5.79 |
| CHEMBL83074 | — | — | 1 | 5.69 |
| CHEMBL87622 | — | — | 1 | 5.59 |
| CHEMBL81895 | — | — | 1 | 5.48 |
| CHEMBL420781 | — | — | 1 | 5.40 |
| CHEMBL87485 | — | — | 1 | 5.39 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.39 |
| CHEMBL313749 | — | — | 1 | 5.39 |
| CHEMBL85645 | — | — | 1 | 5.32 |
| CHEMBL315676 | — | — | 1 | 5.31 |
| CHEMBL84893 | — | — | 1 | 5.27 |
| CHEMBL314420 | — | — | 1 | 5.26 |
| CHEMBL81878 | — | — | 1 | 5.12 |
| CHEMBL313918 | — | — | 1 | 5.05 |
| CHEMBL85460 | — | — | 1 | 5.01 |
| CHEMBL84919 | — | — | 1 | 4.97 |
| CHEMBL86288 | — | — | 1 | 4.85 |
| CHEMBL86197 | — | — | 1 | 4.82 |
| CHEMBL86150 | — | — | 1 | 4.78 |
| CHEMBL85678 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312823 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL84726 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL85264 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL86903 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL85936 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL83074 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL87622 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL81895 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL420781 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL87485 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL14 | CARBACHOL | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL313749 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL85645 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL315676 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL84893 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL314420 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL81878 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL313918 | — | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL85460 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL84919 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL86288 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL86197 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL86150 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL85678 | — | IC50 | = | 26900.0 | nM | 4.57 |