Assay Detail
Binding
CHEMBL748174
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Inhibition of [3H]N-methylscopolamine binding to muscarinic acetylcholine receptor of rat cerebral cortex.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Phenyl-substituted analogues of oxotremorine as muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.24 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51405 | — | — | 1 | 7.25 |
| CHEMBL310852 | — | — | 1 | 7.19 |
| CHEMBL101645 | — | — | 1 | 6.96 |
| CHEMBL97915 | — | — | 1 | 6.92 |
| CHEMBL99266 | — | — | 1 | 6.64 |
| CHEMBL100406 | — | — | 1 | 6.51 |
| CHEMBL318049 | — | — | 1 | 6.27 |
| CHEMBL319665 | — | — | 1 | 5.89 |
| CHEMBL97890 | — | — | 1 | 5.62 |
| CHEMBL99265 | — | — | 1 | 5.28 |
| CHEMBL318528 | — | — | 1 | 5.24 |
| CHEMBL101646 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51405 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL310852 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL101645 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL97915 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL99266 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL100406 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL318049 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL319665 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL97890 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL99265 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL318528 | — | Ki | = | 5770.0 | nM | 5.24 |
| CHEMBL101646 | — | Ki | = | 6910.0 | nM | 5.16 |