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Compound Detail

CHEMBL101646

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O=C1C(c2ccccc2)CCN1CC#CCN1CCCC1

Basic Information

ChEMBL ID CHEMBL101646
Phase Preclinical
Structure Type MOL
InChI Key ABWIEWBRXMOWNZ-UHFFFAOYSA-N
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

282.4
MW (Da)
2.10
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H22N2O
MW 282.39
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -0.46

Activity Summary

Kd 1 meas. best 4.95
Ki 1 meas. best 5.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 5.16 5.16 6910.0 1
Muscarinic acetylcholine receptor
CHEMBL2094109
Kd 4.95 4.95 11210.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1732545 10.1021/jm00080a013 Muscarinic acetylcholine receptor 2
1732545 10.1021/jm00080a013 Mus musculus 1

Data from ChEMBL 36 via Core Engine