Assay Detail
Binding
CHEMBL748213
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Inhibition of 0.03 nM [3H]quinuclidinyl benzylate binding to rat neocortex muscarinic receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.09 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.39 |
| CHEMBL167689 | — | — | 1 | 5.90 |
| CHEMBL163661 | — | — | 1 | 5.71 |
| CHEMBL11081 | — | — | 1 | 5.61 |
| CHEMBL74300 | — | — | 1 | 5.27 |
| CHEMBL353023 | — | — | 1 | 5.24 |
| CHEMBL167419 | — | — | 1 | 5.14 |
| CHEMBL167335 | — | — | 1 | 4.88 |
| CHEMBL168032 | — | — | 1 | 4.43 |
| CHEMBL165985 | — | — | 1 | 4.26 |
| CHEMBL166736 | — | — | 1 | 4.18 |
| CHEMBL75358 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL167689 | — | IC50 | = | 1254.0 | nM | 5.90 |
| CHEMBL163661 | — | IC50 | = | 1928.0 | nM | 5.71 |
| CHEMBL11081 | — | IC50 | = | 2447.0 | nM | 5.61 |
| CHEMBL74300 | — | IC50 | = | 5388.0 | nM | 5.27 |
| CHEMBL353023 | — | IC50 | = | 5696.0 | nM | 5.24 |
| CHEMBL167419 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL167335 | — | IC50 | = | 13230.0 | nM | 4.88 |
| CHEMBL168032 | — | IC50 | = | 36769.0 | nM | 4.43 |
| CHEMBL165985 | — | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL166736 | — | IC50 | = | 65600.0 | nM | 4.18 |
| CHEMBL75358 | — | IC50 | = | 87876.0 | nM | 4.06 |