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Compound Detail

CHEMBL163661

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CC(/C=N/O)CC#CCN1CCCC1

Basic Information

ChEMBL ID CHEMBL163661
Phase Preclinical
Structure Type MOL
InChI Key AVBRLEVRCOCAPV-ZRDIBKRKSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

194.3
MW (Da)
1.57
ALogP
3
HBA
1
HBD
35.8
PSA (Ų)
0.32
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H18N2O
MW 194.28
Aromatic Rings 0
Heavy Atoms 14
NP-Likeness -0.45

Activity Summary

IC50 4 meas. best 7.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.68 6.695 21.0 2
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 6.04 6.04 920.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
IC50 5.26 5.26 5500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80535-1 Muscarinic acetylcholine receptor 3
- 10.1016/S0960-894X(00)80535-1 Muscarinic acetylcholine receptor M2 1
- 10.1016/S0960-894X(00)80535-1 Muscarinic acetylcholine receptor M1 1
- 10.1016/S0960-894X(00)80535-1 Unchecked 1

Data from ChEMBL 36 via Core Engine