Assay Detail
Binding
CHEMBL748432
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Inhibition of 0.1 nM [3H]cis-methyldioxolane binding to rat neocortex muscarinic receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.38 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.82 |
| CHEMBL11081 | — | — | 1 | 8.35 |
| CHEMBL163661 | — | — | 1 | 7.68 |
| CHEMBL75358 | — | — | 1 | 7.67 |
| CHEMBL167335 | — | — | 1 | 7.52 |
| CHEMBL353023 | — | — | 1 | 7.23 |
| CHEMBL74300 | — | — | 1 | 7.19 |
| CHEMBL166736 | — | — | 1 | 7.17 |
| CHEMBL165985 | — | — | 1 | 7.00 |
| CHEMBL168032 | — | — | 1 | 6.86 |
| CHEMBL167419 | — | — | 1 | 6.67 |
| CHEMBL167689 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL11081 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL163661 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL75358 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL167335 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL353023 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL74300 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL166736 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL165985 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL168032 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL167419 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL167689 | — | IC50 | = | 373.0 | nM | 6.43 |