Assay Detail
Binding
CHEMBL745679
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Displacement of [3H]QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.22 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.44 |
| CHEMBL163661 | — | — | 1 | 6.04 |
| CHEMBL11081 | — | — | 1 | 5.61 |
| CHEMBL353023 | — | — | 1 | 5.55 |
| CHEMBL74300 | — | — | 1 | 5.14 |
| CHEMBL167335 | — | — | 1 | 4.59 |
| CHEMBL166736 | — | — | 1 | 4.29 |
| CHEMBL75358 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL163661 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL11081 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL353023 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL74300 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL167335 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL166736 | — | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL75358 | — | IC50 | = | 87880.0 | nM | 4.06 |