Assay Detail
Binding
CHEMBL744023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.15 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.07 |
| CHEMBL11081 | — | — | 1 | 5.70 |
| CHEMBL75358 | — | — | 1 | 5.35 |
| CHEMBL163661 | — | — | 1 | 5.26 |
| CHEMBL353023 | — | — | 1 | 5.19 |
| CHEMBL166736 | — | — | 1 | 4.72 |
| CHEMBL167335 | — | — | 1 | 4.47 |
| CHEMBL74300 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 858.0 | nM | 6.07 |
| CHEMBL11081 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL75358 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL163661 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL353023 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL166736 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL167335 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL74300 | — | IC50 | = | 34116.0 | nM | 4.47 |