Assay Detail
Functional
CHEMBL748335
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The in vitro IC50 value was measured for inhibition of lipid autoxidation in mouse heart homogenate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.92 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95994 | — | — | 1 | 5.16 |
| CHEMBL317128 | — | — | 1 | 5.00 |
| CHEMBL440885 | — | — | 1 | 5.00 |
| CHEMBL87570 | — | — | 1 | 4.72 |
| CHEMBL99134 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95994 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL317128 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL440885 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL87570 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL99134 | — | IC50 | = | 19000.0 | nM | 4.72 |