Assay Detail
Binding
CHEMBL748430
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In vitro inhibition of [3H]quinuclidinyl benzilate (QNB) binding to muscarinic receptors of rat cerebral cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.62 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135645 | — | — | 1 | 6.66 |
| CHEMBL336590 | — | — | 1 | 6.33 |
| CHEMBL135604 | — | — | 1 | 5.96 |
| CHEMBL344892 | — | — | 1 | 5.71 |
| CHEMBL341766 | — | — | 1 | 5.70 |
| CHEMBL350757 | — | — | 1 | 5.64 |
| CHEMBL335324 | — | — | 1 | 5.64 |
| CHEMBL167982 | — | — | 1 | 5.62 |
| CHEMBL137385 | — | — | 1 | 5.52 |
| CHEMBL336162 | — | — | 1 | 5.52 |
| CHEMBL135260 | — | — | 1 | 5.52 |
| CHEMBL341379 | — | — | 1 | 5.51 |
| CHEMBL334674 | — | — | 1 | 5.09 |
| CHEMBL336727 | — | — | 1 | 5.07 |
| CHEMBL135836 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135645 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL336590 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL135604 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL344892 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL341766 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL350757 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL335324 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL167982 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL137385 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL336162 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL135260 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL341379 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL334674 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL336727 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL135836 | — | IC50 | = | 15500.0 | nM | 4.81 |