Compound Detail
CHEMBL350757
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Basic Information
| ChEMBL ID | CHEMBL350757 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | COFRKLYXCWVCKM-UHFGSYKHSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
179.2
MW (Da)
0.46
ALogP
4
HBA
0
HBD
48.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 7.64 | 6.64 | 23.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 23.0 | nM | 7.64 | In vitro inhibition of oxotremorine-M (OXO-M) binding to muscarinic receptors of... | - |
| Muscarinic acetylcholine receptor | IC50 | = | 2300.0 | nM | 5.64 | In vitro inhibition of [3H]quinuclidinyl benzilate (QNB) binding to muscarinic r... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80533-8 | Muscarinic acetylcholine receptor | 3 |
Data from ChEMBL 36 via Core Engine