Assay Detail
Binding
CHEMBL748431
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In vitro inhibition of oxotremorine-M (OXO-M) binding to muscarinic receptors of rat cerebral cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.37 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341379 | — | — | 1 | 8.05 |
| CHEMBL135645 | — | — | 1 | 7.96 |
| CHEMBL344892 | — | — | 1 | 7.72 |
| CHEMBL350757 | — | — | 1 | 7.64 |
| CHEMBL336590 | — | — | 1 | 7.48 |
| CHEMBL341766 | — | — | 1 | 7.47 |
| CHEMBL167982 | — | — | 1 | 7.37 |
| CHEMBL135836 | — | — | 1 | 7.36 |
| CHEMBL336727 | — | — | 1 | 7.29 |
| CHEMBL137385 | — | — | 1 | 7.23 |
| CHEMBL135260 | — | — | 1 | 7.19 |
| CHEMBL135604 | — | — | 1 | 7.16 |
| CHEMBL336162 | — | — | 1 | 7.14 |
| CHEMBL334674 | — | — | 1 | 6.80 |
| CHEMBL335324 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341379 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL135645 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL344892 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL350757 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL336590 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL341766 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL167982 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL135836 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL336727 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL137385 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL135260 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL135604 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL336162 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL334674 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL335324 | — | IC50 | = | 190.0 | nM | 6.72 |