Assay Detail
Binding
CHEMBL748441
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Inhibition of [3H]pirenzepine binding to muscarinic receptor in rat cortical homogenates
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Muscarinic antagonist activity of 3-(5-alkoxy-oxazol-2-yl)-1,2,5,6-tetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.22 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | 4.0 | 1 | 10.10 |
| CHEMBL295365 | — | — | 1 | 9.10 |
| CHEMBL300424 | — | — | 1 | 9.10 |
| CHEMBL45694 | — | — | 1 | 8.82 |
| CHEMBL49915 | — | — | 1 | 8.70 |
| CHEMBL298030 | — | — | 1 | 8.00 |
| CHEMBL48342 | — | — | 1 | 7.96 |
| CHEMBL297794 | — | — | 1 | 7.80 |
| CHEMBL47178 | — | — | 1 | 7.66 |
| CHEMBL46324 | — | — | 1 | 7.60 |
| CHEMBL296552 | — | — | 1 | 7.52 |
| CHEMBL47331 | — | — | 1 | 7.48 |
| CHEMBL49139 | — | — | 1 | 7.05 |
| CHEMBL297896 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569713 | SCOPOLAMINE | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL295365 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL300424 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL45694 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL49915 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL298030 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL48342 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL297794 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL47178 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL46324 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL296552 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL47331 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL49139 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL297896 | — | Ki | > | 1000.0 | nM | - |