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Compound Detail

CHEMBL47178

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CCCCCCOc1oc(C2=CCCN(C)C2)nc1C(C)CC

Basic Information

ChEMBL ID CHEMBL47178
Phase Preclinical
Structure Type MOL
InChI Key ORMJJRVBQZCEFV-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

320.5
MW (Da)
4.87
ALogP
4
HBA
0
HBD
38.5
PSA (Ų)
0.61
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H32N2O2
MW 320.48
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness 0.11

Activity Summary

Ki 1 meas. best 7.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 7.66 7.66 22.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80368-6 Muscarinic acetylcholine receptor 1
- 10.1016/S0960-894X(00)80368-6 Rattus norvegicus 1
- 10.1016/S0960-894X(00)80368-6 Mus musculus 1

Data from ChEMBL 36 via Core Engine