Assay Detail
Binding
CHEMBL748448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovarian |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and characterization of m4 selective muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.34 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092 | TRIHEXYPHENIDYL HYDROCHLORIDE | 4.0 | 1 | 7.99 |
| CHEMBL277642 | HIMBACINE | — | 1 | 5.99 |
| CHEMBL304036 | — | — | 1 | 5.76 |
| CHEMBL61700 | — | — | 1 | 5.69 |
| CHEMBL61412 | — | — | 1 | 5.42 |
| CHEMBL303758 | — | — | 1 | 5.41 |
| CHEMBL59939 | — | — | 1 | 5.39 |
| CHEMBL301041 | — | — | 1 | 5.38 |
| CHEMBL62251 | — | — | 1 | 5.32 |
| CHEMBL61774 | — | — | 1 | 5.24 |
| CHEMBL60142 | — | — | 1 | 5.22 |
| CHEMBL59898 | — | — | 1 | 5.13 |
| CHEMBL300987 | — | — | 1 | 5.09 |
| CHEMBL62247 | — | — | 1 | 5.06 |
| CHEMBL294726 | — | — | 1 | 4.75 |
| CHEMBL58228 | — | — | 1 | 4.57 |
| CHEMBL59347 | — | — | 1 | 4.36 |
| CHEMBL61494 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092 | TRIHEXYPHENIDYL HYDROCHLORIDE | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL277642 | HIMBACINE | IC50 | = | 1016.0 | nM | 5.99 |
| CHEMBL304036 | — | IC50 | = | 1731.8 | nM | 5.76 |
| CHEMBL61700 | — | IC50 | = | 2033.9 | nM | 5.69 |
| CHEMBL61412 | — | IC50 | = | 3807.6 | nM | 5.42 |
| CHEMBL303758 | — | IC50 | = | 3884.2 | nM | 5.41 |
| CHEMBL59939 | — | IC50 | = | 4093.0 | nM | 5.39 |
| CHEMBL301041 | — | IC50 | = | 4187.1 | nM | 5.38 |
| CHEMBL62251 | — | IC50 | = | 4737.0 | nM | 5.32 |
| CHEMBL61774 | — | IC50 | = | 5760.1 | nM | 5.24 |
| CHEMBL60142 | — | IC50 | = | 5999.2 | nM | 5.22 |
| CHEMBL59898 | — | IC50 | = | 7411.7 | nM | 5.13 |
| CHEMBL300987 | — | IC50 | = | 8211.3 | nM | 5.09 |
| CHEMBL62247 | — | IC50 | = | 8624.0 | nM | 5.06 |
| CHEMBL294726 | — | IC50 | = | 17980.7 | nM | 4.75 |
| CHEMBL58228 | — | IC50 | = | 26644.8 | nM | 4.57 |
| CHEMBL59347 | — | IC50 | = | 43462.7 | nM | 4.36 |
| CHEMBL61494 | — | IC50 | = | 47361.5 | nM | 4.33 |