Assay Detail
Functional
CHEMBL748461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its inhibitory activity against T-cell proliferation using murine splenic T-cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.56 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431368 | — | — | 1 | 9.96 |
| CHEMBL65863 | — | — | 1 | 9.85 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.70 |
| CHEMBL275103 | — | — | 1 | 9.64 |
| CHEMBL407332 | — | — | 1 | 9.48 |
| CHEMBL305081 | — | — | 1 | 9.47 |
| CHEMBL264568 | — | — | 1 | 9.47 |
| CHEMBL412791 | — | — | 1 | 9.42 |
| CHEMBL405917 | — | — | 1 | 9.42 |
| CHEMBL266705 | — | — | 1 | 9.41 |
| CHEMBL268110 | — | — | 1 | 9.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431368 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL65863 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL275103 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL407332 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL305081 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL264568 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL412791 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL405917 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL266705 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL268110 | — | IC50 | = | 0.47 | nM | 9.33 |