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Assay Detail

CHEMBL748462

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of murine splenocyte proliferation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 1 — Organism
Curated By Expert

Target

Mus musculus (CHEMBL375)
Type ORGANISM
Organism Mus musculus

Publication

Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.
Chhabra SR, Harty C, Hooi DS, Daykin M, Williams P, Telford G, Pritchard DI, Bycroft BW.
J Med Chem (2003) 46 : 97 -104
PubMed 12502363 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.90 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8608 1 5.52
CHEMBL8483 1 5.40
CHEMBL8785 1 5.37
CHEMBL8560 1 5.30
CHEMBL8784 1 5.22
CHEMBL8463 1 5.20
CHEMBL275081 1 5.16
CHEMBL8738 1 5.16
CHEMBL8830 1 5.10
CHEMBL267527 1 5.05
CHEMBL8972 1 5.00
CHEMBL8609 1 4.90
CHEMBL8849 1 4.82
CHEMBL8862 1 4.77
CHEMBL8450 1 4.68
CHEMBL8799 1 4.48
CHEMBL267931 1 4.28
CHEMBL8755 1 4.28
CHEMBL8766 1 4.22
CHEMBL9031 1 4.05
CHEMBL463321 1 -
CHEMBL8811 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8608 IC50 = 3000.0 nM 5.52
CHEMBL8483 IC50 = 4000.0 nM 5.40
CHEMBL8785 IC50 = 4300.0 nM 5.37
CHEMBL8560 IC50 = 5000.0 nM 5.30
CHEMBL8784 IC50 = 6000.0 nM 5.22
CHEMBL8463 IC50 = 6300.0 nM 5.20
CHEMBL275081 IC50 = 7000.0 nM 5.16
CHEMBL8738 IC50 = 7000.0 nM 5.16
CHEMBL8830 IC50 = 8000.0 nM 5.10
CHEMBL267527 IC50 = 8900.0 nM 5.05
CHEMBL8972 IC50 = 10000.0 nM 5.00
CHEMBL8609 IC50 = 12500.0 nM 4.90
CHEMBL8849 IC50 = 15000.0 nM 4.82
CHEMBL8862 IC50 = 17000.0 nM 4.77
CHEMBL8450 IC50 = 21000.0 nM 4.68
CHEMBL8799 IC50 = 33000.0 nM 4.48
CHEMBL267931 IC50 = 53000.0 nM 4.28
CHEMBL8755 IC50 = 52000.0 nM 4.28
CHEMBL8766 IC50 = 60000.0 nM 4.22
CHEMBL9031 IC50 = 90000.0 nM 4.05
CHEMBL463321 IC50 = 400000.0 nM -
CHEMBL8811 IC50 = 150000.0 nM -