Assay Detail
Functional
CHEMBL748464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for inhibition of murine splenocyte proliferation by [3H]thymidine incorporation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of the marine immunosuppressant microcolin A: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.08 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108730 | — | — | 1 | 10.70 |
| CHEMBL2370423 | — | — | 1 | 8.27 |
| CHEMBL2370420 | — | — | 1 | 8.00 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.75 |
| CHEMBL110373 | — | — | 1 | 7.72 |
| CHEMBL110841 | — | — | 1 | 7.69 |
| CHEMBL110919 | — | — | 1 | 6.42 |
| CHEMBL108980 | — | — | 1 | - |
| CHEMBL432609 | — | — | 1 | - |
| CHEMBL325979 | — | — | 1 | - |
| CHEMBL2370417 | — | — | 1 | - |
| CHEMBL321023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108730 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL2370423 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL2370420 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 17.8 | nM | 7.75 |
| CHEMBL110373 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL110841 | — | EC50 | = | 20.5 | nM | 7.69 |
| CHEMBL110919 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL108980 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL432609 | — | EC50 | > | 668.0 | nM | - |
| CHEMBL325979 | — | EC50 | > | 2400.0 | nM | - |
| CHEMBL2370417 | — | EC50 | > | 781.0 | nM | - |
| CHEMBL321023 | — | EC50 | > | 668.0 | nM | - |