Assay Detail
Binding
CHEMBL748552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for NMDA antagonist activity against [3H]-CGS- 19755 binding in rat cortex preparation
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Competitive NMDA antagonist that base their activity on a unique conformational effect
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.18 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.40 |
| CHEMBL281190 | — | — | 3 | 7.19 |
| CHEMBL282656 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL281190 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL281190 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL282656 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL281190 | — | Ki | > | 1000.0 | nM | - |