Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL748634

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity tested in NIH 3T3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Expert

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines.
Li HY, Wang Y, Yan L, Campbell RM, Anderson BD, Wagner JR, Yingling JM.
Bioorg Med Chem Lett (2004) 14 : 3585 -3588
PubMed 15177480 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.05 6.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL330814 1 6.98
CHEMBL120587 1 6.82
CHEMBL119976 1 6.55
CHEMBL121554 1 6.55
CHEMBL119936 1 6.49
CHEMBL121790 1 6.47
CHEMBL120211 1 6.40
CHEMBL122583 1 6.30
CHEMBL325405 1 6.18
CHEMBL332344 1 6.14
CHEMBL120718 1 5.98
CHEMBL333798 1 5.92
CHEMBL120245 1 5.70
CHEMBL120799 1 5.48
CHEMBL120907 1 5.33
CHEMBL122414 1 5.25
CHEMBL121795 1 4.29
CHEMBL118339 1 -
CHEMBL122524 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL330814 IC50 = 105.0 nM 6.98
CHEMBL120587 IC50 = 152.0 nM 6.82
CHEMBL119976 IC50 = 280.0 nM 6.55
CHEMBL121554 IC50 = 282.0 nM 6.55
CHEMBL119936 IC50 = 326.0 nM 6.49
CHEMBL121790 IC50 = 339.0 nM 6.47
CHEMBL120211 IC50 = 397.0 nM 6.40
CHEMBL122583 IC50 = 500.0 nM 6.30
CHEMBL325405 IC50 = 664.0 nM 6.18
CHEMBL332344 IC50 = 727.0 nM 6.14
CHEMBL120718 IC50 = 1040.0 nM 5.98
CHEMBL333798 IC50 = 1200.0 nM 5.92
CHEMBL120245 IC50 = 2000.0 nM 5.70
CHEMBL120799 IC50 = 3330.0 nM 5.48
CHEMBL120907 IC50 = 4710.0 nM 5.33
CHEMBL122414 IC50 = 5620.0 nM 5.25
CHEMBL121795 IC50 = 51000.0 nM 4.29
CHEMBL118339 IC50 > 20000.0 nM -
CHEMBL122524 IC50 > 20000.0 nM -