Assay Detail
Binding
CHEMBL748715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective small molecule NPY Y5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.96 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299295 | — | — | 1 | 5.49 |
| CHEMBL51884 | — | — | 1 | 5.45 |
| CHEMBL415926 | — | — | 1 | 5.26 |
| CHEMBL48777 | — | — | 1 | 5.14 |
| CHEMBL51542 | — | — | 1 | 4.89 |
| CHEMBL51874 | — | — | 1 | 4.84 |
| CHEMBL299879 | — | — | 1 | 4.79 |
| CHEMBL2113711 | — | — | 1 | 4.76 |
| CHEMBL51138 | — | — | 1 | 4.62 |
| CHEMBL301747 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299295 | — | Ki | = | 3236.0 | nM | 5.49 |
| CHEMBL51884 | — | Ki | = | 3548.0 | nM | 5.45 |
| CHEMBL415926 | — | Ki | = | 5546.0 | nM | 5.26 |
| CHEMBL48777 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL51542 | — | Ki | = | 12981.0 | nM | 4.89 |
| CHEMBL51874 | — | Ki | = | 14454.0 | nM | 4.84 |
| CHEMBL299879 | — | Ki | = | 16032.0 | nM | 4.79 |
| CHEMBL2113711 | — | Ki | = | 17179.0 | nM | 4.76 |
| CHEMBL51138 | — | Ki | = | 23714.0 | nM | 4.62 |
| CHEMBL301747 | — | Ki | = | 48697.0 | nM | 4.31 |