Compound Detail
CHEMBL415926
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Basic Information
| ChEMBL ID | CHEMBL415926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CUXZFDHUMYRJHA-IHJHTLIFSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
476.7
MW (Da)
5.32
ALogP
3
HBA
2
HBD
58.2
PSA (Ų)
0.46
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 CHEMBL4561 | Ki | 7.85 | 7.675 | 14.0 | 2 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | Ki | 5.26 | 5.26 | 5546.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 5 | Ki | = | 14.0 | nM | 7.85 | Tested for radioligand binding affinity against membranes from COS-7 cells trans... | 12067557 |
| Neuropeptide Y receptor type 5 | Ki | = | 32.0 | nM | 7.5 | Displacement of [125I]PYY from human Neuropeptide Y receptor type 5 in COS-7 cel... | 12067558 |
| Neuropeptide Y receptor type 1 | Ki | = | 5546.0 | nM | 5.26 | Tested for radioligand binding affinity against membranes from COS-7 cells trans... | 12067557 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12067557 | 10.1016/s0960-894x(02)00287-1 | Neuropeptide Y receptor type 5 | 2 |
| 12067557 | 10.1016/s0960-894x(02)00287-1 | Neuropeptide Y receptor type 1 | 1 |
| 12067558 | 10.1016/s0960-894x(02)00288-3 | Neuropeptide Y receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine