Assay Detail
Binding
CHEMBL750710
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Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 5
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective small molecule NPY Y5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.76 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299879 | — | — | 1 | 8.10 |
| CHEMBL51542 | — | — | 1 | 8.00 |
| CHEMBL2113711 | — | — | 1 | 8.00 |
| CHEMBL51884 | — | — | 1 | 7.96 |
| CHEMBL51138 | — | — | 1 | 7.85 |
| CHEMBL415926 | — | — | 1 | 7.85 |
| CHEMBL299295 | — | — | 1 | 7.77 |
| CHEMBL51874 | — | — | 1 | 7.58 |
| CHEMBL301747 | — | — | 1 | 7.55 |
| CHEMBL48777 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299879 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL51542 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2113711 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL51884 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL51138 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL415926 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL299295 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL51874 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL301747 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL48777 | — | Ki | = | 123.0 | nM | 6.91 |