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Assay Detail

CHEMBL750709

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]PYY from human Neuropeptide Y receptor type 5 in COS-7 cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type COS-7
Confidence 9 — Direct single protein target
Curated By Expert

Target

Neuropeptide Y receptor type 5 (CHEMBL4561)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.
Finn J, Pelham D, Walker MW, Gluchowski C.
Bioorg Med Chem Lett (2002) 12 : 1771 -1774
PubMed 12067558 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.68 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL445613 1 7.92
CHEMBL415926 1 7.50
CHEMBL49906 1 7.34
CHEMBL52382 1 7.02
CHEMBL298168 1 6.99
CHEMBL298342 1 6.82
CHEMBL299742 1 6.70
CHEMBL296906 1 6.64
CHEMBL299579 1 6.38
CHEMBL296387 1 6.37
CHEMBL52332 1 6.14
CHEMBL50807 1 6.14
CHEMBL48904 1 6.14
CHEMBL48960 1 5.38
CHEMBL297509 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL445613 Ki = 12.0 nM 7.92
CHEMBL415926 Ki = 32.0 nM 7.50
CHEMBL49906 Ki = 46.0 nM 7.34
CHEMBL52382 Ki = 95.0 nM 7.02
CHEMBL298168 Ki = 103.0 nM 6.99
CHEMBL298342 Ki = 151.0 nM 6.82
CHEMBL299742 Ki = 199.0 nM 6.70
CHEMBL296906 Ki = 231.0 nM 6.64
CHEMBL299579 Ki = 412.0 nM 6.38
CHEMBL296387 Ki = 426.0 nM 6.37
CHEMBL52332 Ki = 724.0 nM 6.14
CHEMBL50807 Ki = 724.0 nM 6.14
CHEMBL48904 Ki = 724.0 nM 6.14
CHEMBL48960 Ki = 4120.0 nM 5.38
CHEMBL297509 Ki > 100000.0 nM -