Assay Detail
Binding
CHEMBL748851
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 receptors (m1-QNBm1c2)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.19 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.44 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.35 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.92 |
| CHEMBL37132 | — | — | 1 | 4.90 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL550 | PILOCARPINE | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 11920.0 | nM | 4.92 |
| CHEMBL37132 | — | IC50 | = | 12690.0 | nM | 4.90 |
| CHEMBL14 | CARBACHOL | IC50 | = | 44370.0 | nM | 4.35 |