Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL37132

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCN1C(=O)OC[C@@H]1Cc1cncn1C

Basic Information

ChEMBL ID CHEMBL37132
Phase Preclinical
Structure Type MOL
InChI Key OJXBNCYNASEZSC-VIFPVBQESA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

209.2
MW (Da)
0.80
ALogP
4
HBA
0
HBD
47.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H15N3O2
MW 209.25
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -0.30

Activity Summary

IC50 6 meas. best 7.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.37 6.4733 43.0 3
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 6.54 5.72 288.0 2
Muscarinic acetylcholine receptor M2
CHEMBL309
IC50 4.51 4.51 30910.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M1 4
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor 3
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M3 2
- 10.1016/S0960-894X(01)80787-3 Muscarinic acetylcholine receptor 2
- 10.1016/S0960-894X(01)80787-3 Muscarinic acetylcholine receptor M2 2
- 10.1016/S0960-894X(01)80787-3 Unchecked 1
- 10.1016/S0960-894X(01)80787-3 SK-N-SH 1
- 10.1016/S0960-894X(01)80787-3 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine