Assay Detail
Binding
CHEMBL750969
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Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Heart |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.07 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.06 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.04 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.72 |
| CHEMBL37132 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL550 | PILOCARPINE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL14 | CARBACHOL | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL37132 | — | IC50 | = | 30910.0 | nM | 4.51 |