Assay Detail
Binding
CHEMBL748852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampus
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationships of heterocyclic analogues of the functional M1 selective muscarinic agonist hexyloxy-TZTP
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.64 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101054 | — | — | 1 | 8.30 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 8.15 |
| CHEMBL74786 | — | — | 1 | 6.56 |
| CHEMBL75907 | — | — | 1 | 6.46 |
| CHEMBL355465 | — | — | 1 | 6.43 |
| CHEMBL353779 | — | — | 1 | 6.25 |
| CHEMBL168581 | — | — | 1 | 6.18 |
| CHEMBL166115 | — | — | 1 | 6.15 |
| CHEMBL74300 | — | — | 1 | 6.02 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101054 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL21536 | XANOMELINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL74786 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL75907 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL355465 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL353779 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL168581 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL166115 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL74300 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 1300.0 | nM | 5.89 |