Assay Detail
Binding
CHEMBL749203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards muscarinic receptor M2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.30 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357557 | — | — | 1 | 7.17 |
| CHEMBL348667 | — | — | 1 | 6.79 |
| CHEMBL422326 | — | — | 1 | 6.77 |
| CHEMBL140706 | — | — | 1 | 6.70 |
| CHEMBL322251 | — | — | 1 | 6.60 |
| CHEMBL141699 | — | — | 1 | 6.59 |
| CHEMBL334470 | — | — | 1 | 6.46 |
| CHEMBL311795 | — | — | 1 | 6.24 |
| CHEMBL337820 | — | — | 1 | 6.21 |
| CHEMBL342137 | — | — | 1 | 6.01 |
| CHEMBL140490 | — | — | 1 | 5.96 |
| CHEMBL344607 | — | — | 1 | 5.91 |
| CHEMBL138502 | — | — | 1 | 5.78 |
| CHEMBL140827 | — | — | 1 | 5.69 |
| CHEMBL113436 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357557 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL348667 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL422326 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL140706 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL322251 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL141699 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL334470 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL311795 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL337820 | — | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL342137 | — | Ki | = | 985.0 | nM | 6.01 |
| CHEMBL140490 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL344607 | — | Ki | = | 1225.0 | nM | 5.91 |
| CHEMBL138502 | — | Ki | = | 1678.0 | nM | 5.78 |
| CHEMBL140827 | — | Ki | = | 2031.0 | nM | 5.69 |
| CHEMBL113436 | — | Ki | = | 2500.0 | nM | 5.60 |