Assay Detail
Binding
CHEMBL749332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140784 | — | — | 1 | 7.01 |
| CHEMBL1437288 | — | — | 1 | 6.79 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.76 |
| CHEMBL274323 | ASPARTIC ACID | 3.0 | 1 | 5.79 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140784 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1437288 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL274323 | ASPARTIC ACID | IC50 | = | 1638.0 | nM | 5.79 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | IC50 | = | 4150.0 | nM | 5.38 |