Assay Detail
Binding
CHEMBL749333
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In vitro binding affinity against N-methyl-D-aspartate glutamate receptor using [3H]CGS-19,755 ligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.24 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.27 |
| CHEMBL173031 | — | — | 1 | 6.97 |
| CHEMBL366591 | — | — | 1 | 6.11 |
| CHEMBL173032 | — | — | 1 | 5.64 |
| CHEMBL362277 | — | — | 1 | 5.23 |
| CHEMBL444616 | — | — | 1 | - |
| CHEMBL178746 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL173031 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL366591 | — | IC50 | = | 777.0 | nM | 6.11 |
| CHEMBL173032 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL362277 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL444616 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL178746 | — | IC50 | > | 10000.0 | nM | - |