Compound Detail
CHEMBL173032
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Basic Information
| ChEMBL ID | CHEMBL173032 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGDQEHQWABDAOK-RQJHMYQMSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
225.2
MW (Da)
-0.41
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.64 | 5.365 | 2280.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 2280.0 | nM | 5.64 | In vitro binding affinity against N-methyl-D-aspartate glutamate receptor using ... | 1825117 |
| Glutamate NMDA receptor | IC50 | = | 8100.0 | nM | 5.09 | Compound was evaluated in vitro in a cortical-wedge preparation for the antagoni... | 1825117 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1825117 | 10.1021/jm00105a016 | Glutamate NMDA receptor | 2 |
| 1825117 | 10.1021/jm00105a016 | Rattus norvegicus | 1 |
| 1825117 | 10.1021/jm00105a016 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine