Assay Detail
Functional
CHEMBL749334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated in vitro in a cortical-wedge preparation for the antagonism of N-methyl-D-aspartate-induced responses
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.12 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 5.77 |
| CHEMBL173031 | — | — | 1 | 5.38 |
| CHEMBL173032 | — | — | 1 | 5.09 |
| CHEMBL362277 | — | — | 1 | 4.91 |
| CHEMBL366591 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL173031 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL173032 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL362277 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL366591 | — | IC50 | = | 35200.0 | nM | 4.45 |