Assay Detail
Functional
CHEMBL749648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity against Opioid receptor mu 1 in Chinese hamster ovary membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-aminothiazole-derived opioids. Bioisosteric replacement of phenols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.35 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 9.10 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.80 |
| CHEMBL242756 | — | — | 1 | 7.14 |
| CHEMBL390866 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL301160 | BUTORPHAN | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL242756 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL390866 | — | EC50 | > | 1000.0 | nM | - |