Assay Detail
Binding
CHEMBL749732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cell membranes was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.39 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | — | 1 | 9.10 |
| CHEMBL147511 | — | — | 1 | 8.89 |
| CHEMBL146756 | — | — | 1 | 8.54 |
| CHEMBL433697 | — | — | 1 | 8.13 |
| CHEMBL357334 | — | — | 1 | 8.10 |
| CHEMBL405131 | — | — | 1 | 8.00 |
| CHEMBL346436 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49269 | CYCLORPHAN | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL147511 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL146756 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL433697 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL357334 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL405131 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL346436 | — | EC50 | = | 11.0 | nM | 7.96 |