Assay Detail
Binding
CHEMBL749733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Incorporation of [35S]- GTPgammaS into CHO membranes expressing human Opioid receptor mu 1
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.60 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 8.35 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.26 |
| CHEMBL2367916 | — | — | 1 | 7.82 |
| CHEMBL354172 | — | — | 1 | 7.68 |
| CHEMBL352965 | — | — | 1 | 7.66 |
| CHEMBL169346 | — | — | 2 | 7.21 |
| CHEMBL422560 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2367916 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL354172 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL352965 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL169346 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL169346 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL422560 | — | EC50 | = | 180.0 | nM | 6.75 |