Assay Detail
Functional
CHEMBL749737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of [35S]GTP-gamma-S, binding using COS-human Opioid receptor mu 1 membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.70 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266609 | — | — | 1 | 5.85 |
| CHEMBL355931 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266609 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL355931 | — | EC50 | = | 2800.0 | nM | 5.55 |