Assay Detail
Binding
CHEMBL750211
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Binding affinity against opioid receptor delta by displacement of radioligand [3H]DSLET in rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.08 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2371283 | — | — | 1 | 5.65 |
| CHEMBL2371282 | — | — | 1 | 5.03 |
| CHEMBL436434 | — | — | 1 | 4.90 |
| CHEMBL60444 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2371283 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL2371282 | — | Ki | = | 9290.0 | nM | 5.03 |
| CHEMBL436434 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL60444 | — | Ki | = | 19200.0 | nM | 4.72 |