Assay Detail
Binding
CHEMBL750214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DSLET from rat brain membrane opioid receptor delta
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.54 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15595 | — | — | 1 | 8.60 |
| CHEMBL107580 | — | — | 1 | 8.49 |
| CHEMBL323024 | — | — | 1 | 8.04 |
| CHEMBL321335 | — | — | 1 | 7.81 |
| CHEMBL263021 | — | — | 1 | 7.29 |
| CHEMBL325810 | — | — | 1 | 7.26 |
| CHEMBL106849 | — | — | 1 | 6.68 |
| CHEMBL3037875 | — | — | 1 | 5.80 |
| CHEMBL105453 | — | — | 1 | 5.58 |
| CHEMBL3084310 | — | — | 1 | 5.46 |
| CHEMBL104838 | — | — | 1 | 4.89 |
| CHEMBL105568 | — | — | 1 | 4.85 |
| CHEMBL107906 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15595 | — | Ki | = | 2.53 | nM | 8.60 |
| CHEMBL107580 | — | Ki | = | 3.21 | nM | 8.49 |
| CHEMBL323024 | — | Ki | = | 9.22 | nM | 8.04 |
| CHEMBL321335 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL263021 | — | Ki | = | 50.7 | nM | 7.29 |
| CHEMBL325810 | — | Ki | = | 54.6 | nM | 7.26 |
| CHEMBL106849 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL3037875 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL105453 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3084310 | — | Ki | = | 3510.0 | nM | 5.46 |
| CHEMBL104838 | — | Ki | = | 12800.0 | nM | 4.89 |
| CHEMBL105568 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL107906 | — | Ki | = | 50100.0 | nM | 4.30 |